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M9480157.TXT
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1994-08-09
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Document 0157
DOCN M9480157
TI Automat: a novel software system for the systematic search for protein
(or DNA) similarities with a notable application to autoimmune diseases
and AIDS.
DT 9410
AU Cantalloube H; Nahum C; Achour A; Lehner T; Callebaut I; Burny A;
Bizzini B; Mornon JP; Zagury D; Zagury JF; Universite P. et M. Curie,
Paris, France.
SO Comput Appl Biosci. 1994 Apr;10(2):153-61. Unique Identifier : AIDSLINE
MED/94290911
AB Automat is a novel program which finds exhaustively all the oligopeptide
segments shared by a given protein of any size with the proteins of a
whole databank. It allows the user to collect statistics on the
composition of the sequence studied in reference to the databank used.
We present here the rationale and the algorithm underlying this powerful
software. Besides its immediate interest for identifying efficiently
similarities between proteins (or DNAs), biological applications of this
software have already been described in the case of HIV-1 viral
proteins, and Automat should prove useful also for studying more
generally autoimmune diseases.
DE Acquired Immunodeficiency Syndrome/*GENETICS Algorithms Amino Acid
Sequence Autoimmune Diseases/*GENETICS Human HIV/*CHEMISTRY
Molecular Sequence Data *Sequence Alignment Sequence Analysis, DNA
*Software Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).